Biomanufacturing human tissues via organ building blocks.
Cell Stem Cell
; 29(5): 667-677, 2022 05 05.
Article
em En
| MEDLINE
| ID: mdl-35523137
ABSTRACT
The construction of human organs on demand remains a tantalizing vision to solve the organ donor shortage. Yet, engineering tissues that recapitulate the cellular and architectural complexity of native organs is a grand challenge. The use of organ building blocks (OBBs) composed of multicellular spheroids, organoids, and assembloids offers an important pathway for creating organ-specific tissues with the desired cellular-to-tissue-level organization. Here, we review the differentiation, maturation, and 3D assembly of OBBs into functional human tissues and, ultimately, organs for therapeutic repair and replacement. We also highlight future challenges and areas of opportunity for this nascent field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organoides
/
Engenharia Tecidual
Limite:
Humans
Idioma:
En
Revista:
Cell Stem Cell
Ano de publicação:
2022
Tipo de documento:
Article