Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer.
Biomed Eng Lett
; 12(2): 147-153, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35529340
ABSTRACT
Photoacoustic microscopy (PAM) embedded with a 532 nm pulse laser is widely used to visualize the microvascular structures in both small animals and humans in vivo. An opto-ultrasound combiner (OUC) is often utilized in high-speed PAM to confocally align the optical and acoustic beams to improve the system's sensitivity. However, acoustic impedance mismatch in the OUC results in little improvement in the sensitivity. Alternatively, a ring-shaped ultrasound transducer (RUT) can also accomplish the confocal configuration. Here, we compare the performance of OUC and RUT modules through ultrasound pulse-echo tests and PA imaging experiments. The signal-to-noise ratios (SNRs) of the RUT-based system were 15 dB, 12 dB, and 7 dB higher when compared to the OUC-based system for ultrasound pulse-echo test, PA phantom imaging test, and PA in-vivo imaging test, respectively. In addition, the RUT-based system could image the microvascular structures of small parts of a mouse body in a few seconds with minimal loss in SNR. Thus, with increased sensitivity, improved image details, and fast image acquisition, we believe the RUT-based systems could play a significant role in the design of future fast-PAM systems.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomed Eng Lett
Ano de publicação:
2022
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Article