Sleep, depression, anxiety and fatigue in women with premature ovarian insufficiency.

PURPOSE: To assess sleep disturbances, levels of anxiety, depression and fatigue in women with premature ovarian insufficiency (POI). MATERIALS AND METHODS: The study included 62 women with POI and 62 age-matched controls. Women in both groups completed questionnaires. Pittsburgh Sleep Quality Index, Insomnia severity index, Epworth Sleepiness Scale, Hospital Anxiety and Depression Scale and Fatigue Severity Scale were used. RESULTS: We found poor sleep quality, higher levels of insomnia in women with POI than in controls. Depression was much more prevalent and severe in POI women. Total anxiety score, the severity of anxiety and fatigue did not differ significantly between the groups. According to the multivariable logistic regression analysis, being married and having POI were associated with worse quality of sleep, and having more children was associated with an increase in depression levels in the whole cohort. Backward analysis showed that when POI status was taken as a reference, married women were at 6.5 fold increased risk of poor sleep quality. CONCLUSIONS: Women with premature ovarian failure are more likely to suffer from poor sleep quality, insomnia and depression than healthy women.