Lack of renoprotective effects of targeting the endothelin A receptor and (or) sodium glucose transporter 2 in a mouse model of Type 2 diabetic kidney disease.

Stuart, Deborah; Peterson, Caitlin S; Hu, Chunyan; Revelo, Monica P; Huang, Yufeng; Kohan, Donald E; Ramkumar, Nirupama

Stuart, Deborah; Peterson, Caitlin S; Hu, Chunyan; Revelo, Monica P; Huang, Yufeng; Kohan, Donald E; Ramkumar, Nirupama.

Afiliação

Stuart D; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.
Peterson CS; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.
Hu C; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.
Revelo MP; Department of Pathology, University of Utah Health, Salt Lake City, UT 84112, USA.
Huang Y; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.
Kohan DE; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.
Ramkumar N; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah Health, Salt Lake City, UT 84132, USA.

Can J Physiol Pharmacol ; 100(8): 763-771, 2022 Aug 01.

Article em En | MEDLINE | ID: mdl-35531905

Assuntos

Diabetes Mellitus Tipo 2; Nefropatias Diabéticas; Inibidores do Transportador 2 de Sódio-Glicose; Animais; Masculino; Camundongos; Albuminas/análise; Albuminas/farmacologia; Albuminas/uso terapêutico; Compostos Benzidrílicos/farmacologia; Glicemia/análise; Peso Corporal; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/patologia; Nefropatias Diabéticas/tratamento farmacológico; Nefropatias Diabéticas/patologia; Nefropatias Diabéticas/prevenção & controle; Modelos Animais de Doenças; Glucose/farmacologia; Rim; Receptor de Endotelina A; Transportador 2 de Glucose-Sódio; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia; Inibidores do Transportador 2 de Sódio-Glicose/uso terapêutico

Palavras-chave

SGLT2; combined therapy; diabetic kidney disease; endothelin-A receptor; insuffisance rénale diabétique; récepteurs A de l'endothéline; traitement d'association

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Inibidores do Transportador 2 de Sódio-Glicose Limite: Animals Idioma: En Revista: Can J Physiol Pharmacol Ano de publicação: 2022 Tipo de documento: Article

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