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Long-term antibacterial performances of biodegradable polylactic acid materials with direct absorption of antibiotic agents.
Chen, Chien-Hao; Yao, Yuan-Yuan; Tang, Hao-Che; Lin, Tung-Yi; Chen, Dave W; Cheng, Kong-Wei.
Afiliação
  • Chen CH; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital Keelung Branch Taiwan mr5181@adm.cgmh.org.tw +886-3-3278113 +886-3-3281200-2420.
  • Yao YY; College of Medicine, Chang Gung University Taoyuan Taiwan.
  • Tang HC; Department of Chemical and Materials Engineering, Chang Gung University 259 Wen-Hwa 1st Rd.,Kwei-Shan, 333 Taoyuan Taiwan kwcheng@mail.cgu.edu.tw +886-3-2118668 +886-3-2118800-3353.
  • Lin TY; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital Keelung Branch Taiwan mr5181@adm.cgmh.org.tw +886-3-3278113 +886-3-3281200-2420.
  • Chen DW; College of Medicine, Chang Gung University Taoyuan Taiwan.
  • Cheng KW; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital Keelung Branch Taiwan mr5181@adm.cgmh.org.tw +886-3-3278113 +886-3-3281200-2420.
RSC Adv ; 8(29): 16223-16231, 2018 Apr 27.
Article em En | MEDLINE | ID: mdl-35542195
In this study, polylactic acid (PLA) disks with antibacterial performances were prepared using 3D printing technology combined with direct adsorption of the antibiotic agents in solution baths. The effects of the layer thicknesses for the building of the 3D printing PLA disks and the amounts of antibiotic agents absorbed onto the sample surfaces on their antibacterial activities were investigated. The antibiotic agent release profiles from the samples surface into the buffer solution show that the antibacterial performances of these samples can reach up to 28 days. With a decrease in the concentration of antibiotic agent in the solution bath, the amount of antibiotic agent adsorbed on the sample surfaces also decreases, but their antibacterial performances can still maintain at least 7 days. In the bioactivity tests of the various organisms, the release amount of antibiotic agent from the sample can inhibit E. coli and S. aureus for over 80% up to 28 days. In the antibacterial activity tests, a PLA disk with suitable antibiotic agents covering its surface has a good inhibitory effect on the growth ability of S. aureus of less than 50% in six hours.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Adv Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Adv Ano de publicação: 2018 Tipo de documento: Article