pH-Dependent Conformational Switching of Amide Bondsâfrom Full trans to Full cis and Vice Versa.
Org Lett
; 24(19): 3488-3492, 2022 05 20.
Article
em En
| MEDLINE
| ID: mdl-35544347
ABSTRACT
Strategies enabling the pH-dependent conformational switching of amide bonds from trans to cis, and vice versa, are yet limited in the sense that, in a suitable pH range, one rotamer may be stabilized to a large extent while the complementary pH range only leads to a mixture of isomers. By exploiting the effects of steric demand and the interaction of the amide carbonyl with a positive charge, we herein present the first examples for reversible pH-dependent switching from full trans to full cis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amidas
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2022
Tipo de documento:
Article