Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.
Life Sci
; 303: 120601, 2022 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-35561749
ABSTRACT
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2022
Tipo de documento:
Article