Maternal undernutrition during periconceptional period affects whole-genome ovine muscle methylation in adult offspring.
J Anim Sci
; 100(8)2022 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-35580043
The formation of the epigenetic pattern of an organism is highly sensitive to environmental factors, especially during early mammalian development, when epigenetic reprogramming of the whole genome takes place. In utero adverse conditions experienced during early pregnancy, such as maternal undernutrition, may induce long-lasting epigenetic changes in the resulting offspring. This study investigated the CpG methylation variations in muscle tissue of adult offspring induced by differences in the diet of their mothers during pregnancy. Our data show that undernutrition during pregnancy leads to epigenetic alterations in the muscle of the offspring, with a potential impact on animal health and productivity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Ovinos
/
Desnutrição
Tipo de estudo:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Anim Sci
Ano de publicação:
2022
Tipo de documento:
Article