Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies.

Cheng, Miffy H Y; Brimacombe, Cedric A; Verbeke, Rein; Cullis, Pieter R

Cheng, Miffy H Y; Brimacombe, Cedric A; Verbeke, Rein; Cullis, Pieter R.

Afiliação

Cheng MHY; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Brimacombe CA; Polymorphic BioSciences, Vancouver, British Columbia V6T 1Z3, Canada.
Verbeke R; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Cullis PR; Ghent Research Group on Nanomedicines, Faculty of Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

Mol Pharm ; 19(6): 1663-1668, 2022 06 06.

Article em En | MEDLINE | ID: mdl-35583489

ABSTRACT

ABSTRACT

In this brief perspective, we describe key events in the history of the lipid-based nanomedicine field, highlight Canadian contributions, and outline areas where lipid nanoparticle technology is poised to have a transformative effect on the future of medicine.

Assuntos

Edição de Genes; Nanopartículas; Sistemas CRISPR-Cas; Canadá; Lipossomos

Palavras-chave

CAR-T therapy; CRISPR-Cas9; gene therapy; lipid nanoparticles; mRNA; vaccines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Edição de Genes País/Região como assunto: America do norte Idioma: En Revista: Mol Pharm Ano de publicação: 2022 Tipo de documento: Article

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