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Imaging patterns of cerebral ischemia in hypereosinophilic syndrome: case report and systematic review.
Miethe, Kathrin; Iordanishvili, Elene; Habib, Pardes; Panse, Jens; Krämer, Stefan; Wiesmann, Martin; Schulz, Jörg B; Nikoubashman, Omid; Reich, Arno; Pinho, João.
Afiliação
  • Miethe K; Department of Neurology, University Hospital, RTWH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
  • Iordanishvili E; Department of Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany.
  • Habib P; Department of Neurology, University Hospital, RTWH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
  • Panse J; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany.
  • Krämer S; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, University Hospital, RTWH Aachen University, Aachen, Germany.
  • Wiesmann M; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.
  • Schulz JB; Department of Nephrology and Clinical Immunology, University Hospital, RTWH Aachen University, Aachen, Germany.
  • Nikoubashman O; Department of Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany.
  • Reich A; Department of Neurology, University Hospital, RTWH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
  • Pinho J; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany.
Neurol Sci ; 43(8): 5091-5094, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35590001
INTRODUCTION: Ischemic stroke is a potential complication of hypereosinophilic syndromes (HES), and little is known about underlying pathophysiological mechanisms. We aimed to describe the imaging patterns of cerebral ischemia in patients with HES. METHODS: An individual case is reported. A systematic PubMed review of all records reporting adult patients with HES who suffered ischemic stroke and for whom neuroimaging details of ischemic lesions were available was performed. RESULTS: A 60-year-old man presented with progressive subacute gait difficulty and psychomotor slowing as well as an absolute eosinophilia (2.2 × 109/L) at admission. Brain magnetic resonance tomography revealed multiple acute and subacute internal and external border zone infarcts. Cardiac diagnostic suggested the presence of endomyocarditis. After extensive diagnostic workup, idiopathic HES was diagnosed. The systematic review yielded 183 studies, of which 40 fulfilled the inclusion criteria: a total of 64 patients (31.3% female), with mean age 51.1 years and a median absolute eosinophile count at diagnosis of 10.2 × 109/L were included in the analyses. A border zone pattern of cerebral ischemic lesions was reported in 41 patients (64.1%). Isolated peripheral infarcts were reported in 7 patients (10.9%). Sixteen patients had multiple acute infarcts with no border zone distribution (25.0%). An intracardiac thrombus was reported in 15/60 patients (25%), and findings suggestive of endomyocarditis or endomyocardial fibrosis were found in 31/60 patients (51.7%). CONCLUSIONS: Border zone distribution of cerebral ischemia without hemodynamic compromise is the most frequent imaging pattern in patients with HES, occurring in 2/3 of patients who develop ischemic stroke.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Síndrome Hipereosinofílica / AVC Isquêmico Tipo de estudo: Etiology_studies / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurol Sci Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Síndrome Hipereosinofílica / AVC Isquêmico Tipo de estudo: Etiology_studies / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurol Sci Ano de publicação: 2022 Tipo de documento: Article