Recent advances in immunotoxicity and its impact on human health: causative agents, effects and existing treatments.
Int Immunopharmacol
; 108: 108859, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35598397
ABSTRACT
BACKGROUND:
A strong immune system is a primary requirement to keep the body safe from different ailments and infections. A human knowingly or unknowingly often comes to the exposure of many foreign substances such as pollutants, chemicals, metals and drugs that affect the immune system. Though some of these substances are known to exert immunotoxicity, their precise role as immunotoxicant is still unidentified, hence, the testing of these substances has to be taken into account. The present manuscript aimed to explore the mechanism behind immunotoxicity, biomarkers involved, manifestations, testing of immunotoxicity and its management.METHODS:
Relevant literature on immunotoxicity, collected from online scientific databases like Scopus, PubMed and Google Scholar, was rigorously reviewed.RESULTS:
Earlier reports showed that immunotoxic effects of chemicals and pharmaceuticals may cause various health problems including allergic reactions, skin disorders, respiratory infections, gastrointestinal problems, and autoimmune disorders. If diagnosed in time, many of these conditions can be managed with the help of existing treatments although the complete treatment is sometimes a big challenge.CONCLUSION:
Based on the review of available literature, it can be concluded that immunotoxicity is one of the key factors responsible for several infectious diseases, autoimmune disorders and even cancers. Hence, the requirement of advanced diagnostic tools and established treatments for immunotoxicity is highly recommended.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Poluentes Ambientais
/
Hipersensibilidade
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Int Immunopharmacol
Ano de publicação:
2022
Tipo de documento:
Article