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Cumulative Mycobacterium tuberculosis Infection Incidence (Measured Primarily by Tuberculin Skin Test) Among Infants With Human Immunodeficiency Virus Exposure: Observational Follow-up of an Isoniazid Prophylaxis Trial.
LaCourse, Sylvia M; Escudero, Jaclyn N; Mecha, Jerphason; Warr, A J; Richardson, Barbra A; Carimo, Naziat; Cranmer, Lisa M; Maleche-Obimbo, Elizabeth; Matemo, Daniel; Kinuthia, John; Hawn, Thomas R; John-Stewart, Grace.
Afiliação
  • LaCourse SM; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Escudero JN; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Mecha J; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Warr AJ; Medical Research Department, Kenyatta National Hospital, Nairobi, Kenya.
  • Richardson BA; Department of Pediatrics and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • Carimo N; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Cranmer LM; Department of Biostatistics, University of Washington, Seattle, Washington, USA.
  • Maleche-Obimbo E; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Matemo D; Division of Infectious Diseases, Department of Pediatrics, Emory University, Atlanta, Georgia, USA.
  • Kinuthia J; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
  • Hawn TR; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • John-Stewart G; Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Clin Infect Dis ; 75(12): 2253-2256, 2022 12 19.
Article em En | MEDLINE | ID: mdl-35607710
ABSTRACT
Cumulative 24-month Mycobacterium tuberculosis infection incidence (measured primarily by tuberculin skin test [TST]) was high among human immunodeficiency virus exposed but uninfected infants (8.7 [95% confidence interval, 6.3-11.9] per 100 person-years). Trend for decreased TST positivity among infants at trial end (12 months postenrollment) randomized to isoniazid at 6 weeks of age was not sustained through observational follow-up to 24 months of age. CLINICAL TRIALS REGISTRATION NCT02613169.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Mycobacterium tuberculosis Tipo de estudo: Clinical_trials / Incidence_studies / Risk_factors_studies Limite: Child, preschool / Humans / Infant Idioma: En Revista: Clin Infect Dis Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Tuberculose / Infecções por HIV / Mycobacterium tuberculosis Tipo de estudo: Clinical_trials / Incidence_studies / Risk_factors_studies Limite: Child, preschool / Humans / Infant Idioma: En Revista: Clin Infect Dis Ano de publicação: 2022 Tipo de documento: Article