Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.

He, Xiaochen; Zeng, Heng; Cantrell, Aubrey C; Williams, Quinesha A; Chen, Jian-Xiong

He, Xiaochen; Zeng, Heng; Cantrell, Aubrey C; Williams, Quinesha A; Chen, Jian-Xiong.

Afiliação

He X; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Zeng H; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Cantrell AC; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Williams QA; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Chen JX; Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

J Cell Physiol ; 237(8): 3317-3327, 2022 08.

Article em En | MEDLINE | ID: mdl-35621078

Assuntos

Proteínas Reguladoras de Apoptose; Insuficiência Cardíaca; Fosfofrutoquinases; Monoéster Fosfórico Hidrolases; Animais; Proteínas Reguladoras de Apoptose/metabolismo; Diástole; Modelos Animais de Doenças; Fibrose; Glucose/metabolismo; Glicólise; Insuficiência Cardíaca/genética; Insuficiência Cardíaca/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Miocárdio/enzimologia; Fosfofrutoquinases/metabolismo; Monoéster Fosfórico Hidrolases/metabolismo

Palavras-chave

TIGAR; cardiac fibrosis; diastolic function; glucose metabolism

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Monoéster Fosfórico Hidrolases / Fosfofrutoquinases / Proteínas Reguladoras de Apoptose / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Cell Physiol Ano de publicação: 2022 Tipo de documento: Article

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