Your browser doesn't support javascript.
loading
HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria.
Guerra, Cecilia Victoria Caraballo; da Silva, Bernardo Maia; Müller, Pia; Baia-da-Silva, Djane Clarys; Moura, Marco Antônio Saboia; Araújo, José Deney Alves; Silva, Juan Carlo Santos E; Silva-Neto, Alexandre Vilhena; da Silva Balieiro, Antonio Alcirley; da Costa-Martins, André Guilherme; Melo, Gisely Cardoso; Val, Fernando; Bassat, Quique; Nakaya, Helder I; Martinez-Espinosa, Flor Ernestina; Lacerda, Marcus; Sampaio, Vanderson Souza; Monteiro, Wuelton.
Afiliação
  • Guerra CVC; Universidade Do Estado Do Amazonas, Manaus, Amazonas, Brasil.
  • da Silva BM; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira, 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil.
  • Müller P; Universidade Do Estado Do Amazonas, Manaus, Amazonas, Brasil.
  • Baia-da-Silva DC; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira, 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil.
  • Moura MAS; London School of Hygiene and Tropical Medicine, London, England.
  • Araújo JDA; Universidade Do Estado Do Amazonas, Manaus, Amazonas, Brasil.
  • Silva JCSE; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira, 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil.
  • Silva-Neto AV; Instituto Leônidas and Maria Deane, Fundação Oswaldo Cruz, Manaus, Amazonas, Brazil.
  • da Silva Balieiro AA; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira, 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil.
  • da Costa-Martins AG; USP Centro de Inovação, Universidade de São Paulo, Sao Paulo, Brazil.
  • Melo GC; Departamento de Análises Clínicas E Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Sao Paulo, Brazil.
  • Val F; USP Centro de Inovação, Universidade de São Paulo, Sao Paulo, Brazil.
  • Bassat Q; Departamento de Análises Clínicas E Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Sao Paulo, Brazil.
  • Nakaya HI; Universidade Do Estado Do Amazonas, Manaus, Amazonas, Brasil.
  • Martinez-Espinosa FE; Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Av. Pedro Teixeira, 25, Dom Pedro, Manaus, Amazonas, 69040-000, Brazil.
  • Lacerda M; Instituto Leônidas and Maria Deane, Fundação Oswaldo Cruz, Manaus, Amazonas, Brazil.
  • Sampaio VS; Departamento de Análises Clínicas E Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Sao Paulo, Brazil.
  • Monteiro W; Plataforma Científica Pasteur-USP, Universidade de São Paulo, Sao Paulo, Brazil.
Sci Rep ; 12(1): 9076, 2022 05 31.
Article em En | MEDLINE | ID: mdl-35641592
ABSTRACT
Globally, malaria and human immunodeficiency virus (HIV) are both independently associated with a massive burden of disease and death. While their co-infection has been well studied for Plasmodium falciparum, scarce data exist regarding the association of P. vivax and HIV. In this cohort study, we assessed the effect of HIV on the risk of vivax malaria infection and recurrence during a 4-year follow-up period in an endemic area of the Brazilian Amazon. For the purpose of this study, we obtained clinical information from January 2012 to December 2016 from two databases. HIV screening data were acquired from the clinical information system at the tropical hospital Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD). The National Malaria Surveillance database (SIVEP malaria) was utilized to identify malaria infections during a 4-year follow-up period after diagnosis of HIV. Both datasets were combined via data linkage. Between 2012 and 2016, a total of 42,121 people were screened for HIV, with 1569 testing positive (3.7%). Out of all the patients diagnosed with HIV, 198 had at least one episode of P. vivax malaria in the follow-up. In the HIV-negative group, 711 participants had at least one P. vivax malaria episode. When comparing both groups, HIV patients had a 6.48 [(5.37-7.83); P < 0.0001] (adjusted relative risk) greater chance of acquiring P. vivax malaria. Moreover, being of the male gender [ARR = 1.41 (1.17-1.71); P < 0.0001], Amerindian ethnicity [ARR = 2.77 (1.46-5.28); P < 0.0001], and a resident in a municipality of the Metropolitan region of Manaus [ARR = 1.48 (1.02-2.15); P = 0.038] were independent risk factors associated with an increased risk of clinical malaria. Education ≥ 8 years [ARR = 0.41 (0.26-0.64); P < 0.0001] and living in the urban area [ARR = 0.44 (0.24-0.80); P = 0.007] were associated to a lower risk of P. vivax malaria. A total of 28 (14.1%) and 180 (25.3%) recurrences (at least a second clinical malaria episode) were reported in the HIV-positive and HIV-negative groups, respectively. After adjusting for sex and education, HIV-positive status was associated with a tendency towards protection from P. vivax malaria recurrences [ARR = 0.55 (0.27-1.10); P = 0.090]. HIV status was not associated with hospitalizations due to P. vivax malaria. CD4 + counts and viral load were not associated with recurrences of P. vivax malaria. No significant differences were found in the distribution of parasitemia between HIV-negative and HIV-positive P. vivax malaria patients. Our results suggest that HIV-positive status is a risk factor for vivax malaria infection, which represents an additional challenge that should be addressed during elimination efforts.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Infecções por HIV / Soropositividade para HIV / Malária Vivax Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND / 4_TD Base de dados: MEDLINE Assunto principal: Infecções por HIV / Soropositividade para HIV / Malária Vivax Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article