Effect of resistance training combined with ß-glucan ingestion on bone of ovariectomized mice.
Climacteric
; 25(6): 595-602, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35652470
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the effects of resistance training (RT) combined with prebiotic ß-glucan (BG) ingestion (Saccharomyces cerevisiae) in ovariectomized (OVX) mice.METHODS:
Forty-eight mice were divided into six treatments SHAM group and five OVX groups treated with saline (SAL), alendronate (ALE) (0.1 mg/kg), BG (62.5 mg/kg), RT (climbing a ladder with load) and the combination of BG + RT. All treatments were performed three times per week for 8 weeks starting 38 days after ovariectomy.RESULTS:
OVX effectiveness was confirmed by a reduction in uterus mass (p < 0.05). Femur weight was higher in the SHAM group, followed by the ALE and RT groups with intermediate values and the BG + RT, BG and SAL groups with the lowest values (p < 0.05). The bone mineral density (BMDDEXA) results were higher for the SHAM and RT groups compared to the other groups (p < 0.05). RT provided similar bone mass and resistance to fracture to ALE and SHAM. We found a similar number of osteocytes in the RT and SHAM groups, which was significantly higher than that found in animals receiving BG (p < 0.05). The BG + RT combination increased calcium bone concentration.CONCLUSION:
RT promoted benefits on bone health in the OVX model, which were not complemented by the consumption of BG.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Glucanas
/
Treinamento Resistido
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Climacteric
Ano de publicação:
2022
Tipo de documento:
Article