Are anaplastic lymphoma kinase (ALK) and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation driver biomarkers of pulmonary neuroendocrine tumors (NETs) and carcinomas (NECs)?

Hiddinga, Birgitta; Zwaenepoel, Karen; Janssens, Annelies; Van Meerbeeck, Jan; Pauwels, Patrick

Hiddinga, Birgitta; Zwaenepoel, Karen; Janssens, Annelies; Van Meerbeeck, Jan; Pauwels, Patrick.

Afiliação

Hiddinga B; Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, The Netherlands.
Zwaenepoel K; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.
Janssens A; Department of Pulmonology and Thoracic Oncology, European Reference Network for Rare or Low Prevalence Lung Diseases: ERN-LUNG, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Van Meerbeeck J; Department of Pulmonology and Thoracic Oncology, European Reference Network for Rare or Low Prevalence Lung Diseases: ERN-LUNG, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Pauwels P; Department of Pathology, Antwerp University Hospital, Edegem, Belgium.

Oncotarget ; 13: 800-809, 2022.

Article em En | MEDLINE | ID: mdl-35677534

Assuntos

Tumor Carcinoide; Carcinoma Neuroendócrino; Neoplasias Pulmonares; Tumores Neuroendócrinos; Quinase do Linfoma Anaplásico/genética; Quinase do Linfoma Anaplásico/metabolismo; Biomarcadores/metabolismo; Tumor Carcinoide/genética; Carcinoma Neuroendócrino/genética; DNA/metabolismo; Metilação de DNA; Metilases de Modificação do DNA/genética; Metilases de Modificação do DNA/metabolismo; Enzimas Reparadoras do DNA; Guanina/análogos & derivados; Humanos; Neoplasias Pulmonares/genética; Tumores Neuroendócrinos/genética; Tumores Neuroendócrinos/patologia; O(6)-Metilguanina-DNA Metiltransferase/metabolismo; Estudos Retrospectivos; Temozolomida/uso terapêutico; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

MGMT promoter methylation; anaplastic lymphoma kinase; neuroendocrine carcinoma; neuroendocrine tumor; small cell lung cancer

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumor Carcinoide / Tumores Neuroendócrinos / Carcinoma Neuroendócrino / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Oncotarget Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google