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Neuroprotective Alkamides from the Aerial Parts of Achillea alpina L.
Li, Xiu-Wei; Yue, Hu-Cheng; Wu, Xia; Guo, Qiang; Tian, Jia-Yi; Liu, Zong-Yang; Xiao, Meng; Li, Xiao-Xi; Yu, Lan; Li, Ang; Ning, Zhong-Qi; Zan, Ke; Chen, Xiao-Qing.
Afiliação
  • Li XW; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Yue HC; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Wu X; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Guo Q; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Tian JY; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Liu ZY; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Xiao M; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Li XX; National Institutes for Food and Drug Control, Beijing, 102629, P. R. China.
  • Yu L; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Li A; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Ning ZQ; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Zan K; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, P. R. China.
  • Chen XQ; National Institutes for Food and Drug Control, Beijing, 102629, P. R. China.
Chem Biodivers ; 19(7): e202200218, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35689671
ABSTRACT
Three new alkamides, achilleamide B-D (1-3) along with five known alkamides (4-8) were isolated from the aerial parts of Achillea alpina L. Structures were elucidated by spectroscopic analysis. Modified Mosher's method and electronic circular dichroism (ECD) calculations were introduced for the absolute configuration of 3. The neuroprotective effects of all the compounds were evaluated by 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, with concentration for 50 % of maximal effect (EC50 ) values of 3.16-24.75 µM, and the structure-activity relationship was conducted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Achillea / Neuroblastoma Limite: Humans Idioma: En Revista: Chem Biodivers Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Achillea / Neuroblastoma Limite: Humans Idioma: En Revista: Chem Biodivers Ano de publicação: 2022 Tipo de documento: Article