Activity dependent inhibition of TRPC1/4/5 channels by duloxetine involves voltage sensor-like domain.

Zimova, Lucie; Ptakova, Alexandra; Mitro, Michal; Krusek, Jan; Vlachova, Viktorie

Zimova, Lucie; Ptakova, Alexandra; Mitro, Michal; Krusek, Jan; Vlachova, Viktorie.

Afiliação

Zimova L; Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: Lucie.Zimova@fgu.cas.cz.
Ptakova A; Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic. Electronic address: Alexandra.Ptakova@fgu.cas.cz.
Mitro M; Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University in Prague, Prague, Czech Republic. Electronic address: Michal.Mitro@fgu.cas.cz.
Krusek J; Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: Jan.Krusek@fgu.cas.cz.
Vlachova V; Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: Viktorie.Vlachova@fgu.cas.cz.

Biomed Pharmacother ; 152: 113262, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35691156

Assuntos

Dor; Canais de Cátion TRPC; Cloridrato de Duloxetina/farmacologia; Células HEK293; Humanos; Simulação de Acoplamento Molecular; Canais de Cátion TRPC/genética; Canais de Cátion TRPC/metabolismo

Palavras-chave

Duloxetine; Inhibitor; TRPC channels; TRPC5; Voltage sensor-like domain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Canais de Cátion TRPC Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2022 Tipo de documento: Article

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