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Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study.
Prange, Stéphane; Lin, Zhengyu; Nourredine, Mikail; Danaila, Teodor; Laurencin, Chloé; Lagha-Boukbiza, Ouhaid; Anheim, Mathieu; Klinger, Hélène; Longato, Nadine; Phillipps, Clelie; Voirin, Jimmy; Polo, Gustavo; Simon, Emile; Mertens, Patrick; Rolland, Anne-Sophie; Devos, David; Metereau, Elise; Tranchant, Christine; Thobois, Stéphane.
Afiliação
  • Prange S; Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS, UMR 5229, Bron.
  • Lin Z; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK/FCRIN network, Bron.
  • Nourredine M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, Cologne, Germany.
  • Danaila T; Service de Neurochirurgie fonctionnelle, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.
  • Laurencin C; Department of Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lagha-Boukbiza O; Center for Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Anheim M; Hospices Civils de Lyon, Service de biostatistiques, Lyon, France.
  • Klinger H; Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS, UMR 5229, Bron.
  • Longato N; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK/FCRIN network, Bron.
  • Phillipps C; Univ Lyon, Institut des Sciences Cognitives Marc Jeannerod, CNRS, UMR 5229, Bron.
  • Voirin J; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK/FCRIN network, Bron.
  • Polo G; Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  • Simon E; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
  • Mertens P; Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  • Rolland AS; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
  • Devos D; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch-Graffenstaden, France.
  • Metereau E; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson NS-PARK/FCRIN network, Bron.
  • Tranchant C; Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
  • Thobois S; Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Ann Neurol ; 92(3): 411-417, 2022 09.
Article em En | MEDLINE | ID: mdl-35703252
ABSTRACT
In this one-year prospective study, Parkinson's disease (PD) patients with or without mania following STN-DBS were compared to investigate risk and etiological factors, clinical management and consequences. Eighteen (16.2%) out of 111 consecutive PD patients developed mania, of whom 17 were males. No preoperative risk factor was identified. Postoperative mania was related to ventral limbic subthalamic stimulation in 15 (83%) patients, and resolved as stimulation was relocated to the sensorimotor STN, besides discontinuation or reduction of dopamine agonists and use of low-dose clozapine in 12 patients, while motor and nonmotor outcomes were similar. These findings underpin the prominent role of limbic subthalamic stimulation in postoperative mania. ANN NEUROL 2022;92411-417.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Estimulação Encefálica Profunda Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Ann Neurol Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Estimulação Encefálica Profunda Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Ann Neurol Ano de publicação: 2022 Tipo de documento: Article