Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities.
Phytochemistry
; 201: 113280, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35716716
ABSTRACT
Eleven undescribed tetracyclic triterpenoids, meliazedarachins A-K, along with twenty-six known compounds were isolated from the fruits of Melia azedarach L.. Their structures were determined by HRESIMS, UV, IR, NMR, X-ray diffraction, electronic circular dichroism (ECD) spectra, and the modified Mosher's method. The cytotoxic activities of all the isolates were measured. Meliazedarachin K and mesendanin N showed cytotoxicity against five human cancer cell lines with IC50 values ranging from 9.02 to 31.31 µM. Meliazedarachin K showed significant cytotoxicity against HCT116 cell line with IC50 value of 9.02 ± 0.84 µM. 21α-methylmelianodiol showed significant cytotoxicity against HCT116 and RKO cell lines with IC50 values of 10.16 ± 1.22 and 8.57 ± 0.80 µM, respectively.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Melia azedarach
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Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2022
Tipo de documento:
Article