Lymphadenectomy improves outcome in dogs with resected Kiupel high-grade cutaneous mast cell tumours and overtly metastatic regional lymph nodes.
J Small Anim Pract
; 63(9): 661-669, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35733233
ABSTRACT
INTRODUCTION:
Historically, the prognosis for dogs with stage II Kiupel high-grade cutaneous mast cell tumours has been considered poor.OBJECTIVES:
The aim of this study was to explore the impact of lymphadenectomy on outcome in dogs with Kiupel high-grade cutaneous mast cell tumours and overt regional lymph node metastasis. MATERIAL ANDMETHODS:
Data from dogs with completely staged Kiupel high-grade cutaneous mast cell tumours with overt and/or certain regional lymph node metastasis undergoing excision of the primary tumours and adjuvant medical treatment were extracted. Dogs with a cytological diagnosis of regional lymph node metastasis that did not undergo lymphadenectomy were compared with dogs that underwent lymphadenectomy and had a histological diagnosis of overt lymph node metastasis.RESULTS:
Forty-nine dogs were included, 18 did not undergo lymphadenectomy while 31 underwent lymphadenectomy. Median time to progression was significantly shorter in dogs that did not undergo lymphadenectomy (150 days, 95% confidence interval 129 to 170) compared to the other dogs (229 days, 95% confidence interval 191 to 266). Median survival time was also shorter in dogs that did not undergo lymphadenectomy (250 days, 95% confidence interval 191 to 308) compared to dogs that underwent lymphadenectomy (371 days, 95% confidence interval 311 to 430). On multivariable analysis, lack of lymphadenectomy was associated with higher risk of overall tumour progression (hazard ratio 2.05, 95% confidence interval 1.02 to 4.13), nodal progression (hazard ratio 3.4, 95% confidence interval 1.65 to 7.02) and tumour-related death (hazard ratio 3.63, 95% confidence interval 1.72 to 7.66), whereas tumour size was associated with higher risk of local recurrence (hazard ratio 3.61, 95% confidence interval 1.06 to 13). CLINICALSIGNIFICANCE:
Regional lymphadenectomy may improve outcome in dogs with biologically aggressive cutaneous mast cell tumours.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Cão
/
Mastócitos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Small Anim Pract
Ano de publicação:
2022
Tipo de documento:
Article