Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies.

Wang, Yang; Xie, Huan; Alugubelli, Yugendar R; Ma, Yuying; Xu, Shiqing; Ma, Jing; Liu, Wenshe R; Liang, Dong

Wang, Yang; Xie, Huan; Alugubelli, Yugendar R; Ma, Yuying; Xu, Shiqing; Ma, Jing; Liu, Wenshe R; Liang, Dong.

Afiliação

Wang Y; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Xie H; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Alugubelli YR; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Ma Y; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Xu S; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Ma J; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.
Liu WR; Department of Chemistry, Texas A&M University, College Station, TX 77843, USA.
Liang D; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.

Pharmaceuticals (Basel) ; 15(6)2022 May 27.

Article em En | MEDLINE | ID: mdl-35745595

Palavras-chave

LC-MS/MS; MPI8; MPI8â¢H2O adduct; SARS-CoV-2; method development and validation; pharmacokinetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google