Your browser doesn't support javascript.
loading
Bioinspired Palladium-Catalyzed Intramolecular C(sp3 )-H Activation for the Collective Synthesis of Proline Natural Products.
Li, Quan-Zhe; Hou, Si-Hua; Kang, Jun-Chen; Lian, Peng-Fei; Hao, Yu; Chen, Chao; Zhou, Jia; Ding, Tong-Mei; Zhang, Shu-Yu.
Afiliação
  • Li QZ; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Hou SH; School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Kang JC; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Lian PF; School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Hao Y; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Chen C; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Zhou J; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Ding TM; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
  • Zhang SY; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Angew Chem Int Ed Engl ; 61(33): e202207088, 2022 08 15.
Article em En | MEDLINE | ID: mdl-35751877
ABSTRACT
Bioinspired palladium-catalyzed intramolecular cyclization of amino acid derivatives containing a vinyl iodide moiety by C-H activation enabled rapid access to a wide range of functionalized proline derivatives with an exocyclic olefin. To demonstrate the practicality of this methodology, the functionalized prolines were used as intermediates for the synthesis of several natural products lucentamycin A, oxotomaymycin, oxoprothracarcin, and barmumycin.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Produtos Biológicos Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Produtos Biológicos Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2022 Tipo de documento: Article