Association of single nucleotide polymorphisms in immune-related genes with spontaneous HBsAg seroconversion: A systematic review and meta-analysis.
Int Immunopharmacol
; 110: 108982, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35752129
ABSTRACT
BACKGROUND:
Studies have reported that the immune system modulation genes are involved in the seroconversion during hepatitis B virus (HBV) infection. Here, a systematic review with meta-analysis is implemented on the association of polymorphisms in immune-related genes with the spontaneous hepatitis B surface antigen (HBsAg) seroconversion.METHODS:
A systematic literature search was conducted in the main electronic databases of Scopus, PubMed, and Web of Science before May 2022. Pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association between genetic polymorphisms and the chance of spontaneous HBsAg seroconversion.RESULTS:
A total of 40 studies finally included for meta-analysis of 2 HLA-DP SNPs, 2 HLA-DQ SNPs, 3 IFNL3/4 SNPs, 2 IL10 SNPs, and 5 TNF SNPs. Based on the overall pooled analysis, HLA-DP rs3077 A (OR = 1.47, 95%CI 1.32-1.65), HLA-DP rs9277535 A (OR = 1.48, 95%CI 1.32-1.66), HLA-DQ rs2856718 G (OR = 1.37, 95%CI 1.18-1.59), HLA-DQ rs7453920 A (OR = 1.41, 95%CI 1.04-1.93), IFNL3/4 rs12980275 G (OR = 1.26, 95%CI 1.01-1.58), TNFA rs1799964 T (OR = 1.17, 95%CI 1.02-1.35), and TNFA rs1800630 C (OR = 1.26, 95%CI 1.03-1.55) increased significantly the chance of spontaneous HBsAg seroconversion.CONCLUSION:
This meta-analysis showed that the HLA-DP gene rs3077 and rs9277535 SNPs, HLA-DQ gene rs2856718 and rs7453920 SNPs, IFNL3/4 gene rs12980275 SNP, TNFA gene rs1799964 and rs1800630 SNPs are involved in the spontaneous HBsAg seroconversion.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Hepatite B Crônica
/
Hepatite B
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Int Immunopharmacol
Ano de publicação:
2022
Tipo de documento:
Article