Lymphoma diagnosis: lessons learned from the comparison of histology and cytology associated with flow cytometry.
Ann Biol Clin (Paris)
; 80(2): 157-168, 2022 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-35766066
ABSTRACT
For lymphoma diagnosis, the flow cytometry (FCM) and cytology associated with FCM (C-FCM) performed on fine needle aspiration (FNA) or cell suspension/imprints from fresh tissue display a good concordance (from 85 to 90%) with the diagnosis made using histological data. Herein is reported a retrospective series of discordant cases, five of them are discussed in details, and some recommendations are proposed for the interpretation of C-FCM data. Firstly, this review highlights the importance of analyzing simultaneously the cytological and FCM data. In particular, the cytological data are crucial to interpret FCM data and/or to complete Ab panels when the strategy of the laboratory is to systematically perform a first screening, which don't always allow the detection of lymphoma cells. Secondly, this report underlines that cytology and FCM analysis should be followed by a confrontation/discussion with a pathologist. Finally, C-FCM appears to be a rapid and particularly important technic to guide the choice of the following diagnosis tools (IHC and genetic).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
2022
Tipo de documento:
Article