Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca<sup>2+</sup> influx.

Min, Hyungyu; Kim, Wooseob; Hong, Sehoon; Lee, Sungkyu; Jeong, Jinguk; Kim, Seyun; Seong, Rho H

Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca²⁺ influx.

Min, Hyungyu; Kim, Wooseob; Hong, Sehoon; Lee, Sungkyu; Jeong, Jinguk; Kim, Seyun; Seong, Rho H.

Afiliação

Min H; School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.
Kim W; School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.
Hong S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Lee S; School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.
Jeong J; School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.
Kim S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Seong RH; School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea.

Proc Natl Acad Sci U S A ; 119(27): e2121520119, 2022 07 05.

Article em En | MEDLINE | ID: mdl-35776543

Assuntos

Cálcio; Homeostase; Fosfotransferases (Aceptor do Grupo Álcool); Polifosfatos; Linfócitos T Reguladores; Animais; Cálcio/metabolismo; Diferenciação Celular; Homeostase/imunologia; Camundongos; Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo; Fosfotransferases (Aceptor do Grupo Álcool)/genética; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Polifosfatos/metabolismo; Receptores de Antígenos de Linfócitos T/metabolismo; Linfócitos T Reguladores/enzimologia; Linfócitos T Reguladores/imunologia

Palavras-chave

Ca2+ influx; T cell receptor signaling; inositol phosphate; inositol polyphosphate multikinase; regulatory T cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polifosfatos / Cálcio / Linfócitos T Reguladores / Fosfotransferases (Aceptor do Grupo Álcool) / Homeostase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article

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