Constituents from Chloranthus multistachys and their cytotoxic activities against various human cancer cell lines.
J Asian Nat Prod Res
; 25(4): 330-341, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-35788164
ABSTRACT
Two new furanoeremophilane sesquiterpenoids, namely, 6,9-dioxo-1α,4α-dihydroxy-furanoeremophilane (1) and 4α,5α-epoxy-6,9-dioxo-1α-hydroxyl-furanoeremophilane (2), and 10 known compounds were isolated from the whole plant of Chloranthus multistachys, and compound 3 was converted to derivative 3a. Their structures were determined based on extensive spectroscopic analysis. All compounds were evaluated by using five cancer cell lines PC3, LNcap, A549, K562, and HEL. The derivative 3a exhibited excellent cytotoxic activities, with the IC50 against HEL cells being the lowest at 1.322 ± 0.08 µM, which was comparable to that of the positive control (doxorubicin). Mechanism studies showed that the anticancer activity of 3a may be associated with cell cycle regulation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Sesquiterpenos de Eudesmano
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Asian Nat Prod Res
Ano de publicação:
2023
Tipo de documento:
Article