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Longitudinal Dopamine D2 Receptor Changes and Cerebrovascular Health in Aging.
Karalija, Nina; Johansson, Jarkko; Papenberg, Goran; Wåhlin, Anders; Salami, Alireza; Köhncke, Ylva; Brandmaier, Andreas M; Andersson, Micael; Axelsson, Jan; Riklund, Katrine; Lövdén, Martin; Lindenberger, Ulman; Bäckman, Lars; Nyberg, Lars.
Afiliação
  • Karalija N; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Johansson J; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Papenberg G; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Wåhlin A; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Salami A; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Köhncke Y; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Brandmaier AM; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Andersson M; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Axelsson J; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Riklund K; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Lövdén M; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Lindenberger U; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Bäckman L; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
  • Nyberg L; From the Departments of Radiation Sciences, Diagnostic Radiology (N.K., J.J., K.R., L.N.) and Radiation Physics (A.W., J.A.), Department of Applied Physics and Electronics (A.W.), and Umeå Center for Functional Brain Imaging (UFBI) (N.K., J.J., A.W., A.S., M.A., J.A., K.R., L.N.), Umeå University; A
Neurology ; 99(12): e1278-e1289, 2022 Sep 20.
Article em En | MEDLINE | ID: mdl-35790424
BACKGROUND AND OBJECTIVES: Cross-sectional studies suggest marked dopamine (DA) decline in aging, but longitudinal evidence is lacking. The aim of this study was to estimate within-person decline rates for DA D2-like receptors (DRD2) in aging and examine factors that may contribute to individual differences in DRD2 decline rates. METHODS: We investigated 5-year within-person changes in DRD2 availability in a sample of older adults. At both occasions, PET with 11C-raclopride and MRI were used to measure DRD2 availability in conjunction with structural and vascular brain integrity. RESULTS: Longitudinal analyses of the sample (baseline: n = 181, ages: 64-68 years, 100 men and 81 women; 5-year follow-up: n = 129, 69 men and 60 women) revealed aging-related striatal and extrastriatal DRD2 decline, along with marked individual differences in rates of change. Notably, the magnitude of striatal DRD2 decline was ∼50% of past cross-sectional estimates, suggesting that the DRD2 decline rate has been overestimated in past cross-sectional studies. Significant DRD2 reductions were also observed in select extrastriatal regions, including hippocampus, orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC). Distinct profiles of correlated DRD2 changes were found across several associative regions (ACC, dorsal striatum, and hippocampus) and in the reward circuit (nucleus accumbens and OFC). DRD2 losses in associative regions were associated with white matter lesion progression, whereas DRD2 losses in limbic regions were related to reduced cortical perfusion. DISCUSSION: These findings provide the first longitudinal evidence for individual and region-specific differences of DRD2 decline in older age and support the hypothesis that cerebrovascular factors are linked to age-related dopaminergic decline.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Receptores de Dopamina D2 Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Receptores de Dopamina D2 Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 2022 Tipo de documento: Article