Bruton's tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids.

Kim, Susana S-Y; Sim, Don C N; Carissimo, Guillaume; Lim, Hong-Hwa; Lam, Kong-Peng

Kim, Susana S-Y; Sim, Don C N; Carissimo, Guillaume; Lim, Hong-Hwa; Lam, Kong-Peng.

Afiliação

Kim SS; Singapore Immunology Network, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore. Electronic address: Susana_Kim@immunol.a-star.edu.sg.
Sim DCN; Singapore Immunology Network, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore.
Carissimo G; Infectious Diseases Labs, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore; Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lim HH; Singapore Immunology Network, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore.
Lam KP; Singapore Immunology Network, Agency for Science, Technology & Research (A∗STAR), Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University o

J Biol Chem ; 298(8): 102231, 2022 08.

Article em En | MEDLINE | ID: mdl-35798143

Assuntos

DNA Helicases; RNA Helicases; Proteínas de Ligação a RNA; Grânulos de Estresse; Tirosina Quinase da Agamaglobulinemia/metabolismo; DNA Helicases/genética; DNA Helicases/metabolismo; Fosforilação; Poli I-C; Proteínas de Ligação a Poli-ADP-Ribose/genética; Proteínas de Ligação a Poli-ADP-Ribose/metabolismo; Multimerização Proteica; RNA Helicases/genética; RNA Helicases/metabolismo; Proteínas com Motivo de Reconhecimento de RNA/genética; Proteínas com Motivo de Reconhecimento de RNA/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Tirosina

Palavras-chave

antiviral stress granules; innate immunity; stress granule condensation; tyrosine kinase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / DNA Helicases / RNA Helicases / Grânulos de Estresse Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article

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