Disposition of nalbuphine in patients undergoing general anaesthesia.
Br J Anaesth
; 59(5): 572-5, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-3580238
ABSTRACT
The pharmacokinetics of nalbuphine 20 mg i.v. were studied in 10 patients undergoing lower abdominal or body surface surgery. Blood sampling was carried out for 600 min after injection and drug concentrations were measured by HPLC using electrochemical detection. Disposition was best described as a triexponential function, with a mean elimination half-life of 135.5 min. Mean residence time, clearance, and volumes of distribution, Vss and V beta, were determined by a model independent method, and gave mean values of 149.7 min (MRT), 1095 ml min-1 (ClP), 159.9 litre (Vss) and 207.1 litre (V beta).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anestesia Geral
/
Morfinanos
/
Nalbufina
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
1987
Tipo de documento:
Article