High throughput and high confidence sequence variant analysis in therapeutic antibodies using Evosep One liquid chromatography tandem mass spectrometry with synthetic heavy peptides.

Greer, Tyler; Johnson, Reid O'Brien; Nie, Song; Cejkov, Milos; Zheng, Xiaojing; Li, Ning

Greer, Tyler; Johnson, Reid O'Brien; Nie, Song; Cejkov, Milos; Zheng, Xiaojing; Li, Ning.

Afiliação

Greer T; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States. Electronic address: tyler.greer@regeneron.com.
Johnson RO; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States.
Nie S; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States.
Cejkov M; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States.
Zheng X; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States.
Li N; Analytical Chemistry, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States.

J Pharm Biomed Anal ; 219: 114925, 2022 Sep 20.

Article em En | MEDLINE | ID: mdl-35810724

Assuntos

Peptídeos; Espectrometria de Massas em Tandem; Cromatografia Líquida/métodos; Peptídeos/química; Espectrometria de Massas em Tandem/métodos

Palavras-chave

High-throughput; Liquid chromatography tandem mass spectrometry; Sequence variant analysis; Therapeutic antibody; Validation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Espectrometria de Massas em Tandem Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2022 Tipo de documento: Article

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