Detecting traumatic brain injury-induced coagulopathy: What we are testing and what we are not.
J Trauma Acute Care Surg
; 94(1S Suppl 1): S50-S55, 2023 01 01.
Article
em En
| MEDLINE
| ID: mdl-35838367
ABSTRACT
ABSTRACT Coagulopathy after traumatic brain injury (TBI) is common and has been closely associated with poor clinical outcomes for the affected patients. Traumatic brain injury-induced coagulopathy (TBI-IC) is consumptive in nature and evolves rapidly from an injury-induced hypercoagulable state. Traumatic brain injury-induced coagulopathy defined by laboratory tests is significantly more frequent than clinical coagulopathy, which often manifests as secondary, recurrent, or delayed intracranial or intracerebral hemorrhage. This disparity between laboratory and clinical coagulopathies has hindered progress in understanding the pathogenesis of TBI-IC and developing more accurate and predictive tests for this severe TBI complication. In this review, we discuss laboratory tests used in clinical and research studies to define TBI-IC, with specific emphasis on what the tests detect and what they do not. We also offer perspective on developing more accurate and predictive tests for this severe TBI complication.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Lesões Encefálicas
/
Trombofilia
/
Lesões Encefálicas Traumáticas
Limite:
Humans
Idioma:
En
Revista:
J Trauma Acute Care Surg
Ano de publicação:
2023
Tipo de documento:
Article