Research progress on the interaction between long noncoding RNAs and RNAbinding proteins to influence the reprogramming of tumor glucose metabolism (Review).
Oncol Rep
; 48(3)2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35856447
ABSTRACT
As epigenetic regulators, long noncoding RNAs (lncRNAs) are involved in various important regulatory processes and typically interact with RNAbinding proteins (RBPs) to exert their core functional effects. An increasing number of studies have demonstrated that lncRNAs can regulate the occurrence and development of cancer through a variety of complex mechanisms and can also participate in tumor glucose metabolism by directly or indirectly regulating the Warburg effect. As one of the metabolic characteristics of tumor cells, the Warburg effect provides a large amount of energy and numerous intermediate products to meet the consumption demands of tumor metabolism, providing advantages for the occurrence and development of tumors. The present review article summarizes the regulatory effects of lncRNAs on the reprogramming of glucose metabolism after interacting with RBPs in tumors. The findings discussed herein may aid in the better understanding of the pathogenesis of malignancies, and may provide novel therapeutic targets, as well as new diagnostic and prognostic markers for human cancers.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Longo não Codificante
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Oncol Rep
Ano de publicação:
2022
Tipo de documento:
Article