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Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier.
Sharma, Ram; Chatterjee, Esha; Mathew, Jacob; Sharma, Sachin; Rao, N Vijayakameswara; Pan, Chun-Hsu; Lee, Sung-Bau; Dhingra, Ashwani; Grewal, Ajmer S; Liou, Jing Ping; Guru, Santosh K; Nepali, Kunal.
Afiliação
  • Sharma R; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 110031, Taiwan.
  • Chatterjee E; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, India.
  • Mathew J; Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 106335, Taiwan.
  • Sharma S; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 110031, Taiwan.
  • Rao NV; Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, 106335, Taiwan.
  • Pan CH; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 110031, Taiwan; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taiwan.
  • Lee SB; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taiwan; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taiwan.
  • Dhingra A; Dept. of Pharmaceutical Sciences, Guru Gobind Singh College of Pharmacy, Near Guru Nanak Khalsa College, Yamuna Nagar, 135001, Haryana, India.
  • Grewal AS; Dept. of Pharmaceutical Sciences, Guru Gobind Singh College of Pharmacy, Near Guru Nanak Khalsa College, Yamuna Nagar, 135001, Haryana, India.
  • Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 110031, Taiwan.
  • Guru SK; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, India. Electronic address: santoshkumar.guru@niperhyd.ac.in.
  • Nepali K; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 110031, Taiwan. Electronic address: nepali@tmu.edu.tw.
Eur J Med Chem ; 240: 114602, 2022 Oct 05.
Article em En | MEDLINE | ID: mdl-35858522
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pulmonares / Antineoplásicos Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pulmonares / Antineoplásicos Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article