A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes.
J Liposome Res
; 33(2): 144-153, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-35875973
ABSTRACT
OBJECTIVE:
To investigate the preparation of novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and verify its curative effects and mechanism.METHODS:
By applying a uniform experiment design to investigate the fitting combination of BAPL. Encapsulation Efficiency Evaluation of BAPL Preparation; Particle Size and Surface Potential Evaluation of BAPL Biological activity; Cerebral ischaemia models of rats Evaluation of BAPL curative effects and mechanism.RESULTS:
(1) The fitting combination of lecithin, Cholesterol, AP mass and the borneol mass was 60 mg, 60 mg, 45 mg and 5 mg. the highest encapsulation efficiency was 80.4%, the particle size was 179.1 nm, and the surface zeta potential was -17.2 mV. It conforms to the nano-material standards. (2) The results of animal experiments show that In the BAPL group, the infarct volume of TTC staining was significantly decreased, and the expression levels of NF-κBp65, TLR-4, IL-8, IL-6, IL-1ß in brain tissue were significantly decreased, while the expression levels of ZO-1, ZO-2, IL-10 were significantly increased after cerebral ischaemia-reperfusion.CONCLUSION:
BAPL is a novel nano and effective material for anti-cerebral ischaemia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
/
Lipossomos
Limite:
Animals
Idioma:
En
Revista:
J Liposome Res
Ano de publicação:
2023
Tipo de documento:
Article