Learning what not to select for in antibody drug discovery.
Cell Rep Methods
; 2(7): 100258, 2022 07 18.
Article
em En
| MEDLINE
| ID: mdl-35880020
ABSTRACT
Identifying antibodies with high affinity and target specificity is crucial for drug discovery and development; however, filtering out antibody candidates with nonspecific or polyspecific binding profiles is also important. In this issue of Cell Reports Methods, Saksena et al. report a computational counterselection method combining deep sequencing and machine learning for identifying nonspecific antibody candidates and demonstrate that it has advantages over more established molecular counterselection methods.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Anticorpos
Idioma:
En
Revista:
Cell Rep Methods
Ano de publicação:
2022
Tipo de documento:
Article