Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation.
Nat Commun
; 13(1): 4173, 2022 07 26.
Article
em En
| MEDLINE
| ID: mdl-35882835
ABSTRACT
Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were then treated with or without cytokine adsorption during ex vivo lung perfusion (EVLP) and/or post-transplantation using extracorporeal hemoperfusion. The treatment significantly decreased cytokine levels during EVLP and decreased levels of immune cells post-transplantation. Histology demonstrated fewer signs of lung injury across both treatment periods and the incidence of PGD was significantly reduced among treated animals. Overall, cytokine adsorption was able to restore lung function and reduce PGD in lung transplantation. We suggest this treatment will increase the availability of donor lungs and increase the tolerability of donor lungs in the recipient.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
/
Transplante de Pulmão
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Disfunção Primária do Enxerto
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2022
Tipo de documento:
Article