Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41.
J Antibiot (Tokyo)
; 75(9): 509-513, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35918479
ABSTRACT
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a "heat shock metabolite" (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Termotolerância
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2022
Tipo de documento:
Article