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Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human.
Escobar Sanabria, David; Aman, Joshua E; Zapata Amaya, Valentina; Johnson, Luke A; Farooqi, Hafsa; Wang, Jing; Hill, Meghan; Patriat, Remi; Sovell-Brown, Kelly; Molnar, Gregory F; Darrow, David; McGovern, Robert; Cooper, Scott E; Harel, Noam; MacKinnon, Colum D; Park, Michael C; Vitek, Jerrold L.
Afiliação
  • Escobar Sanabria D; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: escobad2@ccf.org.
  • Aman JE; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Zapata Amaya V; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Johnson LA; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Farooqi H; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Wang J; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Hill M; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Patriat R; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Sovell-Brown K; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Molnar GF; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Darrow D; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA.
  • McGovern R; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Cooper SE; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Harel N; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • MacKinnon CD; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Park MC; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Vitek JL; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: vitek004@umn.edu.
Brain Stimul ; 15(5): 1111-1119, 2022.
Article em En | MEDLINE | ID: mdl-35921960
Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 13-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical pulses with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Our results highlight the utility of eiDBS to characterize the role of oscillatory dynamics in PD and other brain conditions, and to develop personalized neuromodulation systems.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estimulação Encefálica Profunda Limite: Humans Idioma: En Revista: Brain Stimul Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Estimulação Encefálica Profunda Limite: Humans Idioma: En Revista: Brain Stimul Ano de publicação: 2022 Tipo de documento: Article