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Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu, Hin; Hou, Yuxin; Yang, Dong; Wen, Lei; Shuai, Huiping; Yoon, Chaemin; Shi, Jialu; Chai, Yue; Yuen, Terrence Tsz-Tai; Hu, Bingjie; Li, Cun; Zhao, Xiaoyu; Wang, Yixin; Huang, Xiner; Lee, Kin Shing; Luo, Cuiting; Cai, Jian-Piao; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Zhang, Anna Jinxia; Yuan, Shuofeng; Sit, Ko-Yung; Foo, Dominic Chi-Chung; Au, Wing-Kuk; Wong, Kenneth Kak-Yuen; Zhou, Jie; Kok, Kin-Hang; Jin, Dong-Yan; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.
Afiliação
  • Chu H; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China. hinchu@hku.hk.
  • Hou Y; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China. hinchu@hku.hk.
  • Yang D; Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China. hinchu@hku.hk.
  • Wen L; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, China. hinchu@hku.hk.
  • Shuai H; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Yoon C; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Shi J; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Chai Y; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Yuen TT; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Hu B; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Li C; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Zhao X; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Wang Y; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Huang X; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Lee KS; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Luo C; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Cai JP; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Poon VK; Transgenic Core Facility, Centre for Comparative Medicine Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Chan CC; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Zhang AJ; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Yuan S; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Sit KY; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, China.
  • Foo DC; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Au WK; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, China.
  • Wong KK; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Zhou J; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Kok KH; Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
  • Jin DY; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, China.
  • Chan JF; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
  • Yuen KY; Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China.
Nature ; 609(7928): 785-792, 2022 09.
Article em En | MEDLINE | ID: mdl-35922005
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Replicação Viral / Ácido Aspártico / Infecções por Coronavirus / Coronavirus / Cisteína / Caspase 6 / Interações Hospedeiro-Patógeno Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Replicação Viral / Ácido Aspártico / Infecções por Coronavirus / Coronavirus / Cisteína / Caspase 6 / Interações Hospedeiro-Patógeno Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2022 Tipo de documento: Article