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The deleterious effects of old social partners on Drosophila lifespan and stress resistance.
Lin, Yu-Chiao; Zhang, MingYang; Wang, Sheng-Hao; Chieh, Chia-Wen; Shen, Pin-Yun; Chen, Yi-Lin; Chang, Yu-Chia; Kuo, Tsung-Han.
Afiliação
  • Lin YC; Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
  • Zhang M; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
  • Wang SH; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
  • Chieh CW; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
  • Shen PY; National Hsinchu Girls' Senior High school, Hsinchu, Taiwan, Republic of China.
  • Chen YL; National Hsinchu Girls' Senior High school, Hsinchu, Taiwan, Republic of China.
  • Chang YC; Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China.
  • Kuo TH; Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. thkuo@life.nthu.edu.tw.
NPJ Aging ; 8(1): 1, 2022 Mar 18.
Article em En | MEDLINE | ID: mdl-35927252
ABSTRACT
Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the social modulation of aging remains poorly investigated. The present study used the fruit fly, Drosophila melanogaster, as a model to study lifespan and stress resistance under different social conditions. Our experiments first showed that social isolation increased fly lifespan, suggesting a potential deleterious effect of social companions. Furthermore, we exposed flies to different aged social partners and found that living with old animals significantly reduced lifespan and stress resistance in young animals. In contrast, living with young animals increased old animal lifespan, although the effects were less robust. Overall, our results suggest that while social interaction can influence fly health, specific social partners may have more pronounced effects than others. This study provides new evidence that different social environments have significant impacts on animal physiology and longevity.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Aging Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Aging Ano de publicação: 2022 Tipo de documento: Article