The mouse homolog of the mutant WASp responsible for human X-linked neutropenia renders granulopoiesis ineffective.

Ikeda, Masahiro; Futami, Muneyoshi; Chanda, Bidisha; Kobayashi, Masayuki; Izawa, Kiyoko; Tojo, Arinobu

Ikeda, Masahiro; Futami, Muneyoshi; Chanda, Bidisha; Kobayashi, Masayuki; Izawa, Kiyoko; Tojo, Arinobu.

Afiliação

Ikeda M; Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan; Division of Palliative Therapy, Palliative Care Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Japan.
Futami M; Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan; Project Division of Innovative Diagnostics Technology Platform, The Institute of Medical Science, The University of Tokyo, Japan. Electronic address: m-futami@ims.u-tok
Chanda B; Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan.
Kobayashi M; Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan; Department of Hematology, Tokyo Metropolitan Bokutoh Hospital, Japan.
Izawa K; Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan.
Tojo A; Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan; Institute of Innovation Advancement, Tokyo Medical and Dental University, Japan.

Biochem Biophys Res Commun ; 622: 177-183, 2022 09 24.

Article em En | MEDLINE | ID: mdl-35932529

Assuntos

Neutropenia; Vespas; Actinas/metabolismo; Animais; Síndrome Congênita de Insuficiência da Medula Óssea/genética; Hematopoese/genética; Humanos; Camundongos; Neutropenia/genética; Neutrófilos/metabolismo; Proteína da Síndrome de Wiskott-Aldrich/genética; Proteína da Síndrome de Wiskott-Aldrich/metabolismo

Palavras-chave

Severe congenital neutropenia; WASp; Wiskott-Aldrich syndrome; X-linked neutropenia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vespas / Neutropenia Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article

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