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Preparation and characterization of a self-crosslinking sodium alginate-bioactive glass sponge.
Gong, Wensheng; Liu, Lingling; Luo, Liping; Ji, Lijun.
Afiliação
  • Gong W; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
  • Liu L; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
  • Luo L; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
  • Ji L; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
J Biomed Mater Res B Appl Biomater ; 111(1): 173-183, 2023 01.
Article em En | MEDLINE | ID: mdl-35938837
In this research, bioactive glass particles prepared by the reactive flash nanoprecipitation method (RFNP-BG particles) are used to crosslink sodium alginate to prepare biological sponges (SA-BG sponges) by freeze-drying. An experiment for the cross-linking mechanism confirms that the continuous release of Ca2+ from RFNP-BG is promoted by the crosslinking reaction and in turn leads to the gelation process of SA. Bioactive glass particles not only provide Ca2+ for the crosslinking of sodium alginate, but also enhance the mechanical properties of the SA-BG sponges. The results show that the elastic modulus of the SA-BG sponges increases from 0.026 MPa to 0.641 MPa, and the resistance to external force deformation is greatly improved; the thermal decomposition temperature increases from 105°C to 166°C; compared with a pure SA sponge, the water resistance is significantly improved. In vitro cell experiments show that the SA-BG sponges have a certain adverse effect on cell proliferation, but it is in an acceptable range. qPCR results show that the SA-BG sponges have a certain beneficial effect on promoting osteogenic gene expression. The SA-BG sponges have great application potential in the fields of medicine, hemostasis, and wound closure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alginatos / Vidro Idioma: En Revista: J Biomed Mater Res B Appl Biomater Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alginatos / Vidro Idioma: En Revista: J Biomed Mater Res B Appl Biomater Ano de publicação: 2023 Tipo de documento: Article