Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-&#954;B and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.

Xia, Mingjie; Zhang, Yanan; Wu, Honghui; Zhang, Qinyang; Liu, Qiangxian; Li, Guangshen; Zhao, Tianyu; Liu, Xuepeng; Zheng, Shengnai; Qian, Zhanyang; Li, Haijun

Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.

Xia, Mingjie; Zhang, Yanan; Wu, Honghui; Zhang, Qinyang; Liu, Qiangxian; Li, Guangshen; Zhao, Tianyu; Liu, Xuepeng; Zheng, Shengnai; Qian, Zhanyang; Li, Haijun.

Afiliação

Xia M; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhang Y; Postgraduate School, Dalian Medical University, Dalian, China.
Wu H; Postgraduate School, Dalian Medical University, Dalian, China.
Zhang Q; Postgraduate School, Dalian Medical University, Dalian, China.
Liu Q; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Li G; School of Medicine, Nantong University, Nantong, China.
Zhao T; Postgraduate School, Dalian Medical University, Dalian, China.
Liu X; School of Medicine, Nantong University, Nantong, China.
Zheng S; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address: zsn3280@sina.com.
Qian Z; School of Medicine, Southeast University, Nanjing, China; Spine Center, Zhongda Hospital of Southeast University, Nanjing, China. Electronic address: spineqzy@126.com.
Li H; Department of Orthopedics, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China; Taizhou Clinical Medical School of Nanjing Medical University, Taizhou, China. Electronic address: 13901436563@139.com.

Int Immunopharmacol ; 111: 109120, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35944463

Assuntos

Anti-Inflamatórios; Ácidos Cafeicos; Glucosídeos; NF-kappa B; Traumatismos da Medula Espinal; Animais; Anti-Inflamatórios/uso terapêutico; Apoptose; Ácidos Cafeicos/uso terapêutico; Glucosídeos/uso terapêutico; Inflamação/tratamento farmacológico; Sistema de Sinalização das MAP Quinases; Camundongos; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Medula Espinal; Traumatismos da Medula Espinal/complicações; Traumatismos da Medula Espinal/tratamento farmacológico

Palavras-chave

Forsythoside B; NF-κB; Neuro-inflammation; Neuronal apoptosis; Spinal cord injury; p38-MAPK

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Ácidos Cafeicos / NF-kappa B / Glucosídeos / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2022 Tipo de documento: Article

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