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In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay.
Brecklinghaus, Tim; Albrecht, Wiebke; Duda, Julia; Kappenberg, Franziska; Gründler, Lisa; Edlund, Karolina; Marchan, Rosemarie; Ghallab, Ahmed; Cadenas, Cristina; Rieck, Adrian; Vartak, Nachiket; Tolosa, Laia; Castell, José V; Gardner, Iain; Halilbasic, Emina; Trauner, Michael; Ullrich, Anett; Zeigerer, Anja; Demirci Turgunbayer, Özlem; Damm, Georg; Seehofer, Daniel; Rahnenführer, Jörg; Hengstler, Jan G.
Afiliação
  • Brecklinghaus T; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany. Electronic address: brecklinghaus@ifado.de.
  • Albrecht W; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Duda J; Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.
  • Kappenberg F; Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.
  • Gründler L; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Edlund K; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Marchan R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Ghallab A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, 83523 Qena, Egypt.
  • Cadenas C; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Rieck A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Vartak N; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.
  • Tolosa L; Experimental Hepatology Unit, Health Research Institute La Fe, Valencia, Spain.
  • Castell JV; Experimental Hepatology Unit, Health Research Institute La Fe, Valencia, Spain; Biochemistry Department, University of Valencia and CIBEREHD.
  • Gardner I; Simcyp (A Certara Company), Sheffield, UK.
  • Halilbasic E; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Ullrich A; Primacyt Cell Culture Technology GmbH, Schwerin, Germany.
  • Zeigerer A; Institute for Diabetes and Cancer, Helmholtz Center Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany.
  • Demirci Turgunbayer Ö; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany; Department of Biology, Faculty of Science, Dicle University, 21280, Diyarbakir, Turkey.
  • Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, 04103 Leipzig, Germany.
  • Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, 04103 Leipzig, Germany.
  • Rahnenführer J; Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.
  • Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany. Electronic address: hengstler@ifado.de.
Toxicol Lett ; 368: 33-46, 2022 Sep 01.
Article em En | MEDLINE | ID: mdl-35963427
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Fígado Gorduroso / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Toxicol Lett Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Fígado Gorduroso / Doença Hepática Induzida por Substâncias e Drogas Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Toxicol Lett Ano de publicação: 2022 Tipo de documento: Article