DNA repair inhibitors and radiotherapy.
Cancer Radiother
; 26(6-7): 947-954, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35987813
ABSTRACT
Radiotherapy (RT) is one of the main cancer treatments and grows in importance due to improved techniques. DNA damage caused by ionizing radiation creates DNA strand breaks that trigger an intervention of DNA repair pathways involving numerous proteins and enzymes. In recent years, we have identified DNA repair inhibitors as targets for inhibiting cellular repair systems and thus causing cell death. Combining RT with these DNA repair inhibitors appears to be a new approach for cancer treatment, but safety and real efficiency of this combination in practice is unclear. Numerous trials are underway in various diseases and initial results are promising overall, yet remain controversial.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Reparo do DNA
Limite:
Humans
Idioma:
En
Revista:
Cancer Radiother
Ano de publicação:
2022
Tipo de documento:
Article