Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives.
Blood Rev
; 57: 100996, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-35989139
ABSTRACT
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in clonal proliferation of abnormally differentiated hematopoietic cells. In this review, mechanisms contributing to myeloid leukemogenesis are summarized, highlighting aberrations of epigenetics, transcription factors, signal transduction, cell cycling, and the bone marrow microenvironment. The mechanisms contributing to AML are detailed to spotlight recent findings that convey clinical impact. The applications of current and prospective therapeutic targets are accentuated in addition to reviews of treatment paradigms stratified for each characteristic molecular lesion - with a focus on exploring novel treatment approaches and combinations to improve outcomes in AML.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
Limite:
Humans
Idioma:
En
Revista:
Blood Rev
Ano de publicação:
2023
Tipo de documento:
Article