Somatic ablation of IKKß in liver and leukocytes is not tolerated in obese mice but hepatic IKKß deletion improves fatty liver and insulin sensitivity.

Silva, Vagner Ramon R; Molinaro, Angela; Gaudi, Andrea Usseglio; Fryk, Emanuel; Sardi, Claudia; Hammarlund, Maria; Mjörnstedt, Filip; Johansson, Maria E; Becattini, Barbara; Jansson, Per-Anders; Solinas, Giovanni

Silva, Vagner Ramon R; Molinaro, Angela; Gaudi, Andrea Usseglio; Fryk, Emanuel; Sardi, Claudia; Hammarlund, Maria; Mjörnstedt, Filip; Johansson, Maria E; Becattini, Barbara; Jansson, Per-Anders; Solinas, Giovanni.

Afiliação

Silva VRR; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Molinaro A; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Gaudi AU; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Fryk E; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Sardi C; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Hammarlund M; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Mjörnstedt F; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Johansson ME; Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Becattini B; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Jansson PA; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Solinas G; The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

FASEB J ; 36(9): e22512, 2022 09.

Article em En | MEDLINE | ID: mdl-36001064

Assuntos

Fígado Gorduroso; Resistência à Insulina; Animais; Fígado Gorduroso/metabolismo; Quinase I-kappa B/genética; Quinase I-kappa B/metabolismo; Leucócitos/metabolismo; Fígado/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Obesos; Obesidade/metabolismo; Receptor 3 Toll-Like/metabolismo

Palavras-chave

endoplasmic reticulum stress; immunometabolism; liver; metabolic inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Fígado Gorduroso Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: FASEB J Ano de publicação: 2022 Tipo de documento: Article

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