Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.

Zhang, Ziyang; Morstein, Johannes; Ecker, Andrew K; Guiley, Keelan Z; Shokat, Kevan M

Zhang, Ziyang; Morstein, Johannes; Ecker, Andrew K; Guiley, Keelan Z; Shokat, Kevan M.

Afiliação

Zhang Z; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, United States.
Morstein J; Department of Chemistry, University of California Berkeley, Berkeley, California 94720, United States.
Ecker AK; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, United States.
Guiley KZ; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, United States.
Shokat KM; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, United States.

J Am Chem Soc ; 144(35): 15916-15921, 2022 09 07.

Article em En | MEDLINE | ID: mdl-36001446

Assuntos

Neoplasias; Proteínas Proto-Oncogênicas p21(ras); Arginina; Genes ras; Humanos; Ligantes; Mutação; Proteínas Proto-Oncogênicas p21(ras)/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Neoplasias Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article

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