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Assisted Reproductive Technology and Risk of Childhood Cancers.
Weng, Shiue-Shan; Huang, Yen-Tsung; Huang, Yi-Ting; Li, Yi-Ping; Chien, Li-Yin.
Afiliação
  • Weng SS; Institute of Public Health, National Yang Ming Chiao Tung University, Yang-Ming Campus, Taipei City, Taiwan.
  • Huang YT; Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan.
  • Huang YT; Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan.
  • Li YP; Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei City, Taiwan.
  • Chien LY; Institute of Community Health Care, National Yang Ming Chiao Tung University, Yang-Ming Campus, Taipei City, Taiwan.
JAMA Netw Open ; 5(8): e2230157, 2022 08 01.
Article em En | MEDLINE | ID: mdl-36044210
ABSTRACT
Importance The number of children born through the use of assisted reproductive technology (ART) has been increasing. These children may have higher risks for epigenetic alteration and adverse perinatal outcomes, which may be associated with childhood cancers.

Objective:

To determine the associations between different modes of conception and childhood cancers and potential mediation by preterm birth and low birth weight. Design, Setting, and

Participants:

This nationwide, population-based cohort study included registry data from 2 308 016 eligible parents-child triads in Taiwan from January 1, 2004, to December 31, 2017. A total of 1880 children with incident childhood cancer were identified. Data were analyzed between September 1, 2020, and June 30, 2022. Exposure Mode of conception, defined as (1) natural conception, (2) subfertility and non-ART (ie, infertility diagnosis but no ART-facilitated conception), or (3) ART (ie, infertility diagnosis and ART-facilitated conception). Main Outcomes and

Measures:

Diagnosis of childhood cancer according to the International Classification of Childhood Cancers, Third Edition.

Results:

The mean (SD) paternal and maternal ages were 33.28 (5.07) and 30.83 (4.56) years, respectively. Of the 2 308 016 children, 52.06% were boys, 8.16% were born preterm, and 7.38% had low birth weight. During 14.9 million person-years of follow-up (median, 6 years [IQR, 3-10 years]), ART conception was associated with an increased risk of any type of childhood cancers compared with natural conception (hazard ratio, 1.58; 95% CI, 1.17-2.12) and subfertility with non-ART conception (hazard ratio, 1.42; 95% CI, 1.04-1.95). The increased cancer risk of children conceived with ART was mainly owing to leukemia and hepatic tumor. The increased cancer risk associated with ART conception was not mediated by preterm birth or low birth weight. Conclusions and Relevance In this cohort study, children conceived via ART had a higher risk of childhood cancers than those conceived naturally and those born to parents with an infertility diagnosis did not use ART. The increased risk could not be explained by preterm birth or low birth weight.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nascimento Prematuro / Infertilidade / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: JAMA Netw Open Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nascimento Prematuro / Infertilidade / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: JAMA Netw Open Ano de publicação: 2022 Tipo de documento: Article